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Mental Disorders and Gut Health

Your gut and brain are more connected than you think. In other words, what you eat can significantly influence your mental health.

By Sania Siddiqa / Edited by Jaysukh Singh

Updated October 7, 2024

Your gut and brain are linked

Feeling your stomach drop, comes from a place of anxiety or fear, it's an emotion that's mediated by the brain, but how could it affect your stomach and give you that gut-wrenching feeling?

Well, turns out your gut and brain are more connected than you think, after all, your gut is the second brain of your body.

The environment of your gut can highly affect your brain perception and is even said to be associated with mental health issues.

Gut microbiota

Gut microbiota refers to the microorganisms residing in your gut, they can range from bacteria to fungi.

Some microbiota make up your normal flora, i.e. they help your body be healthy and function normally while also protecting it from harmful microbiota, these good organisms are your body's normal flora.

Some microorganisms even govern the mental disorders that plague our society today, including anxiety, depression, bipolar and even schizophrenia.

Researchers believe that a balanced and enriched diet can pave the way for the body to become healthy, causing a marked decrease in symptoms of mental health disorders and balancing out your body's microbiota.

Anxiety

WHO explains that, "Anxiety disorders are characterized by excessive fear and worry and related behavioral disturbances. Symptoms are severe enough to result in significant distress or significant impairment in functioning."

It states that in 2019, 301 million people were living with an anxiety disorder including 58 million children and adolescents.

Anxiety is a gut-dropping feeling that you may experience when you are in the limelight, but it can morph into a medical condition if it hinders your everyday life.

Researchers have found that individuals and experimental lab mice suffering from anxiety usually have less microbiome diversity in their gut, this could be linked to their poor mental health and anxious condition. Currently, researchers are focused on the genus hierarchy of the microbiomes and more specific work is required on the species-level approach towards understanding anxiety-related gut microorganisms.

Depression

According to the World Health Organization, "During a depressive episode, the person experiences a depressed mood (feeling sad, irritable, empty) or a loss of pleasure or interest in activities, for most of the day, nearly every day, for at least two weeks."

The feeling can also cause suicidal tendencies, future homelessness, disturbed sleep, alternation in appetite, and much more.

One experiment that studied 5,558 Chinese individuals found that women who were infected with Helicobacter pylori were more prone to depression compared to men. H. pylori are the ones that cause stomach ulcers.

Another study reported that the transfer of fecal microbiomes from depressive patients to healthy mice could cause the specimen to suffer from depression-like behavior.

Furthermore, a reversal of the previous study was conducted, where microbiota from healthy rats were transplanted into a depressive rat, leading to a reduction in bacteria that can cause depression.

Bipolar disorder

The people who suffer from this disorder are defined by the WHO as "People with bipolar disorder experience alternating depressive episodes with periods of manic symptoms."

The depression episode is characterized by feelings of sadness and loss of pleasure etc, while the manic symptoms make a person hyperactive, with the feeling of euphoria and bliss.

The study compared 39 bipolar patients with 58 healthy patients and found that the micrograms in both cases were not entirely dissimilar, but it could also be due to the individual characteristics of the person.

The research suggests that people suffering from Bipolar disorder have some raised level of microorganisms that healthy individuals don't possess.

More research is required to get towards concrete solutions, work needs to be done on different populations to help understand the disease.

Schizophrenia

"Schizophrenia is characterized by significant impairments in perception and changes in behavior. Symptoms may include persistent delusions, hallucinations, disorganized thinking, highly disorganized behavior, or extreme agitation."

The symptoms are divided into positive and negative symptoms, positive symptoms are those that are additional to the person's life, like hallucinations and delusions.

Negative symptoms refer to the condition when people withdraw from society and lose interest in everyday life.

Subsequently, a study that compared 92 medication-free patients of schizophrenia and 81 healthy patients, found that several bacteria that were present in the schizophrenia patient were absent in the control group.

Using your diet to fight mental disorder

Diet can aid in the fight against microbiome imbalance, these can include probiotics, prebiotics, and postbiotics.

Probiotics

Probiotics are living bacteria that provide us with health benefits when they are used.

A good source of probiotics is yogurt, which is filled with enriched nutrients and bacteria to keep you healthy.

A study that encompassed 423 women, showed that the probiotics (specfically Lactobacillus rhamnosus), alleviated the levels of depression and anxiety in women during postpartum time.

A mixture of probiotics formulation when tested on 156 patients with symptoms of mental disorders, showed a decrease in the said symptoms and better sleep.

Prebiotics and postbiotics

Prebiotics and postbiotics also play a key role in the prevention and handling of mental disorders. Prebiotics are the food that the good bacteria in your body need to survive and make your body healthy Postbiotics are the digested products of prebiotics and probiotics.

A study focused on the administration of post-biotics, prebiotics plant extract, and nutrients to people suffering from mental disorders. This leads to a decrease in symptoms of the disease and an increase in the good microbiota.

A common and more popular post-biotic dietary fiber has been shown to regulate gut microbiota in patients suffering from schizophrenia.

Dairy and spices

Unknown to many, dairy foods and spices can also play a huge role in the prevention and management of mental health disorders.

It has been studied that people who conceive these products have an increase in good microbial and a decrease in depressive and anxious symptoms.

Sources

https://doi.org/10.3390/nu15143258

https://who.int/news-room/fact-sheets/detail/mental-disorders